Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression
Mutations in p53 and RAS potently cooperate in oncogenic transformation, and 3282770208962 correspondingly, these genetic alterations frequently coexist in pancreatic ductal adenocarcinoma (PDA) and other human cancers.Previously, we identified a set of genes synergistically activated by combined RAS and p53 mutations as frequent downstream mediato